- Stefan Brogren as Archie Simpson, the principal of Degrassi and an alumnus of Degrassi Junior High School and Degrassi High School.
- Tom Melissis as Dom Perino, the strict history teacher.
- Michael Kinney as Darryl Armstrong, the reasonable math and gym teacher.
- Aisha Alfa as Ms. Grell, the Remedial room teacher.
- Ashley Comeau as Ms. Badger, the Chemistry teacher.
- Michael Brown as Mr. Mitchell, the Creative Writing teacher.
- Pay Chen as Mrs. Lin, the Mandarin teacher.
|Episode #||Title||Canadian Airdate on F2N (Family)||International/|
U.S. Airdate on Netflix
|1–10||20 (Degrassi: Next Class -Season 6)||TBA||TBA||2001–|