Seniors (Class of 2018)
- Jamie Bloch as Yael Baron, a strong and young wannabe entrepeneur who's been labeled as the next Mark Zuckerberg.
- Sara Waisglass as Frankie Hollingsworth, Hunter's twin sister and Miles' younger sister who's misunderstood.
- Spencer MacPherson as Hunter Hollingsworth, a mysterious introvert who's Frankie's twin brother.
- Amir Bageria as Baaz Nahir, an entrepreneurial millionaire trapped in the body of a 10th grade nerd.
- Amanda Arcuri as Lola Pacini, a boy-crazy cheerleader with colorful hair who goes through with an abortion.
- Reiya Downs as Shay Powers, a girl with a plan who has high standards and is determined to be one of the school's top athletes.
- Dante Scott as Vijay Maraj, a hopeless romantic with a flare for the dramatic.
Freshmen (Class of 2021)
- Stefan Brogren as Archie Simpson, the principal of Degrassi and an alumnus of Degrassi Junior High School and Degrassi High School.
- Tom Melissis as Dom Perino, the strict history teacher.
- Michael Kinney as Darryl Armstrong, the reasonable math and gym teacher.
- Aisha Alfa as Ms. Grell, the Remedial room teacher.
- Ashley Comeau as Ms. Badger, the Chemistry teacher.
- Michael Brown as Mr. Mitchell, the Creative Writing teacher.
- Pay Chen as Mrs. Lin, the Mandarin teacher.
|Episode #||Title||Canadian Airdate on F2N (Family)||International/|
U.S. Airdate on Netflix
|1–10||20 (Degrassi: Next Class -Season 6)||TBA||TBA||2001–|
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